Hesperidin and quercetin may play an effective role in regulating insulin metabolism metabolism in diabetes.

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PMID:  Pharmacogn Mag. 2018 Apr-Jun;14(54):167-173. Epub 2018 Apr 10. PMID: 29720826 Abstract Title:  The Effects of Hesperidin and Quercetin on Serum Tumor Necrosis Factor-Alpha and Interleukin-6 Levels in Streptozotocin-induced Diabetes Model. Abstract:  Background: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications.Objective: In this study, it was aimed to investigate the effects of(HP) and, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes.Materials and Methods: The experimental animals were divided into four groups, each group comprising ten rats designated as follows: Group 1 served as control rats (C); Group 2 served as diabetic rats (DM); Group 3 served as diabetic rats administered HP (DM + HP) (100 mg/kg b. w.); and Group 4 served as diabetic rats administered(DM + Q) (100 mg/kg b. w.).Results: Serum MDA and GSH levels were significantly higher in STZ-induced DM group than control group (

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